Protein name:
Follistatin-related protein 3 ;
Alternative:
Follistatin-related gene protein ;Follistatin-like protein 3 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.
Function:
The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Subcellular Location:
Secreted
Nucleus
Protein Attributes:
50:
MRSGALWPLL | WGALVWTVGS | VGAVMGSEDS | VPGGVCWLQQ | GREATCSLVL |
100:
KTRVSREECC | ASGNINTAWS | NFTHPGNKIS | LLGFLGLVHC | LPCKDSCDGV |
150:
ECGPGKACRM | LGGRPHCECV | PNCEGLPAGF | QVCGSDGATY | RDECELRTAR |
200:
CRGHPDLRVM | YRGRCQKSCA | QVVCPRPQSC | LVDQTGSAHC | VVCRAAPCPV |
250:
PSNPGQELCG | NNNVTYISSC | HLRQATCFLG | RSIGVRHPGI | CTGGPKVPAE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
ELISA Kit for Mouse Follistatin-related protein 3
ELISA Kit for Mouse Follistatin-related protein 3
ELISA Kit for Mouse Follistatin-related protein 3
ELISA Kit for Mouse Follistatin-related protein 3
CLIA Kit for Mouse Follistatin-related protein 3
CLIA Kit for Mouse Follistatin-related protein 3
CLIA Kit for Mouse Follistatin-related protein 3
CLIA Kit for Mouse Follistatin-related protein 3
Polyclonal Antibody for Mouse Follistatin-related protein 3
Polyclonal Antibody for Mouse Follistatin-related protein 3
Polyclonal Antibody for Mouse Follistatin-related protein 3
Polyclonal Antibody for Mouse Follistatin-related protein 3
Monoclonal Antibody for Mouse Follistatin-related protein 3
Monoclonal Antibody for Mouse Follistatin-related protein 3
Monoclonal Antibody for Mouse Follistatin-related protein 3
Monoclonal Antibody for Mouse Follistatin-related protein 3
Protein for Mouse Follistatin-related protein 3
Protein for Mouse Follistatin-related protein 3
Protein for Mouse Follistatin-related protein 3
Protein for Mouse Follistatin-related protein 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH INHBA
strain :
C57BL/6 .
2.
"Mouse follistatin-related protein FLRG (mouse PCTF35, PC12 cell derived trophic factor 35)."
Uchiyama Y.
,
Ohsawa Y.
,
Kametaka S.
Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Kidney .
5.
"Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development."
Takehara-Kasamatsu Y.
,
Tsuchida K.
,
Nakatani M.
,
Murakami T.
,
Kurisaki A.
,
Hashimoto O.
,
Ohuchi H.
,
Kurose H.
,
Mori K.
,
Kagami S.
,
Noji S.
,
Sugino H.
J. Med. Invest.54:276-288(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY